They had three children, two of whom were:
- Domingo Roxas, founder of Casa Roxas, progenitor of Ayala Corporation, and father of Margarita Roxas de Ayala, one of the most successful businesswomen. This branch led to the Ayala, Zobel and Soriano families
- Antonio Roxas y Ureta (1834-1888) who married Lucina Arroyo. Their 12 children would marry into the Araneta, Brias. Manio and Fernandez families.
The Roxas family memebers, according to Salvador Araneta, spelled their surname with either "j" or an "x" after the Spanish pronunciation of the name. Araneta posied three possible ancestors of the Roxas family:
- Francisco de Rojas, the son of Pedro de ROjas and Ines Martinez, a native of Granada who sailed for the Indias in 1527.
- Antonio Fernandez de Roxas, who landed as pilot of the San Jose galleon that arrived from Acapulco, Mexico. Don Antonio was born in the Canary Islands, and settled in Manila. He became the admiral of the Nuestra Señroa del Rosario and was awarded an encomienda in Palawan in 1715. He married twice with his second wife being Teresa Gutierrez y Escaño.
- Pedro Rojas, an oidor or justice of the Real Audiencia
- Margarita Roxas de Ayala (1826-1869), considered the first Filipino philanthropist and the greatest businessperson of her time
- Don Jose Bonifacio Roxas (1834-1888), younger brother of Margarita Roxas de Ayala and father of Pedro Pablo Roxas. In 1851 he would purchase the former Jesuit estate of Hacienda de San Pedro de Macati, which would become the future basis of the Zobel de Ayala Family wealth.
- Felix Roxas y Fernandez (1864-1936) would become the mayor of Manila from 1905 to 1917.
- Felix Roxas y Arroyo (1820-?), father of Felix Roxas y Fernandez, the first Filipino qualified architect
- Felipe Roxas y Arroyo (1840-1899), the painter who emigrated to Paris
- Pedro Pablo Roxas (1847-1912), one of the richest Filipinos at the turn of 20th century, the first manager of San Miguel Brewery
- Francisco Roxas (1851-1897), second cousin of Pedro Pablo Roxas, a musician turned businessman who was falsely accused of complicity with the Katipunan. He was one of the "13 Martyrs of Bagumbayan.
- President Manuel Roxas (1892-1948), grandson of Antonio Roxas, descended from the Capiz branch
- Senator Gerardo Roxas, son of the president
- Antonio J. Roxas, present chairman of board of Roxas & Company, Inc. and chairman emeritus of Roxas Holdings, and director of Central Azucarero Don Pedro
To see the database of members of the Roxas Family, click Roxas Family Database