Domingo Imperial was a former Senator (1934–1935, 1941–1947) of the Sixth Senatorial District of Albay, Sorsogon, Camarines Norte, Camarines Sur, and Masbate. He belonged to the popular Imperial political clan from the province of Albay.
His brothers are Leoncio Imperial, also a former Senator (1916-1922); Carlos A. Imperial, a former Congressman (1907-1909) and Jose Imperial, a former Governor. His son was Carlos D. Imperial, a former Congressman (1965-1972, 1987-1998, 2001-2007) and her daughter-in-law Norma Imperial, a former Congresswoman (1998-2001), Carlos D. Imperial's widower.